Bullets
Local anesthetics
a. action: decreases nerve membrane permeability to sodium ion influx
b. examples
i. topical: benzocaine, cocaine, lidocaine HCL (Xylocaine)
ii. spinal: dibucaine (Nupercaine), procaine HCL (Novocaine)
iii. nerve block: bupivacaine HCL (Marcaine), mepivacaine HCL (Carbocaine)
c. use: pain control while client is conscious
d. adverse effects
i. allergic reactions
ii. respiratory arrest
iii. arrhythmias, cardiac arrest
iv. convulsions
v. hypotension
e. nursing interventions
i. have oxygen and emergency equipment available
ii. monitor vital signs during local anesthesia
iii. if spinal anesthesia, keep client flat for 6-12 hours to prevent headaches
General anesthetics
a. action: depresses the CNS through a progressive sequence
b. examples
i. inhalation anesthetics: cyclopropane, enflurane (Ethrane), ether, nitrous oxide
ii. IV barbiturates: thiopental sodium (Pentothal), methohexital sodium (Brevital)
iii. IV and IM nonbarbiturates: midazolam HCL (Versed), ketamine HCL (Ketaject)
c. use: used in combination for surgical anesthesia
d. adverse effects
i. inhalation anesthetics: excitement and restlessness, nausea and vomiting, respiratory distress
ii. IV barbiturates: respiratory depression, hypotension, tachycardia, laryngospasm
iii. IV and IM nonbarbiturates: respiratory failure, hyper/hypotension, rigidity, psychiatric disturbances
e. contraindications
i. CVA
ii. increased intracranial pressure
iii. severe hypertension
iv. cardiac decompensation
f. nursing interventions
i. have oxygen and emergency treatment available
ii. monitor vital signs
iii. use precautions if agent flammable
iv. use safety precautions when client induced
b. examples
i. inhalation anesthetics: cyclopropane, enflurane (Ethrane), ether, nitrous oxide
ii. IV barbiturates: thiopental sodium (Pentothal), methohexital sodium (Brevital)
iii. IV and IM nonbarbiturates: midazolam HCL (Versed), ketamine HCL (Ketaject)
c. use: used in combination for surgical anesthesia
d. adverse effects
i. inhalation anesthetics: excitement and restlessness, nausea and vomiting, respiratory distress
ii. IV barbiturates: respiratory depression, hypotension, tachycardia, laryngospasm
iii. IV and IM nonbarbiturates: respiratory failure, hyper/hypotension, rigidity, psychiatric disturbances
e. contraindications
i. CVA
ii. increased intracranial pressure
iii. severe hypertension
iv. cardiac decompensation
f. nursing interventions
i. have oxygen and emergency treatment available
ii. monitor vital signs
iii. use precautions if agent flammable
iv. use safety precautions when client induced
Antianxiety (Anxiolytic)
a. action: depress CNS
b. examples
i. benzodiazepines: alprazolam (Xanax), chlordiazepoxide (Librium):physical dependency and withdrawl finsings after long term use
ii. azapirones: buspirone (Buspar)
c. uses: anxiety, sleep disorders, alcohol withdrawal
d. adverse reactions
i. CNS disturbances: dizziness drowsiness, lethargy, orthostatic hypotension
ii. skin rash
iii. blood dyscrasias
e. contraindications
i. hypersensitivity
ii. acute narrow angle glaucoma
iii. liver disease
f. nursing interventions
i. notify health care provider if systolic BP drops 20mm Hg
ii. administer with food or milk
iii. teach client
• take medication as prescribed
• do not take OTC medication without health care provider's approval
• use caution when driving or hazardous activities
• action potentiated with alcohol or sedatives
• never abruptly stop taking benodiazepine
• with chlordiazepoxide- avoid excessive sunlight
Hypnotics
a. action: depress CNS
b. examples
i. barbiturates: pentobarbital (Nembutal), secobarbital (Seconal): physical dependency may result with long term use
ii. acetylinic alcohol: ethchlorvynol (Placidyl)
iii. chloral derivatives: chloral hydrate (Noctec)
c. uses: insomnia, sedation
d. adverse reaftions
i. respiratory depression
ii. hypotension
iii. barbiturate toxicity: hypotension, pulmonary constriction, cold and clammy skin, cyanosis of lips, insomnia, hallucinations, delirium
e. contraindications
i. hypersensitivity
ii. pregnancy
f. nursing interventions
i. monitor client response to medication
ii. teach client
• take medication exactly as prescribed
• avoid alcohol and other depressant use
• avoid driving and other hazardous activities while under the influence
b. examples
i. barbiturates: pentobarbital (Nembutal), secobarbital (Seconal): physical dependency may result with long term use
ii. acetylinic alcohol: ethchlorvynol (Placidyl)
iii. chloral derivatives: chloral hydrate (Noctec)
c. uses: insomnia, sedation
d. adverse reaftions
i. respiratory depression
ii. hypotension
iii. barbiturate toxicity: hypotension, pulmonary constriction, cold and clammy skin, cyanosis of lips, insomnia, hallucinations, delirium
e. contraindications
i. hypersensitivity
ii. pregnancy
f. nursing interventions
i. monitor client response to medication
ii. teach client
• take medication exactly as prescribed
• avoid alcohol and other depressant use
• avoid driving and other hazardous activities while under the influence
Antipsychotics
a. action blocks dopamine hydrochloride receptors in the CNS and sympathetic nervous system
b. examples
i. phenothiazines: chlorpromazine (Thorazine), thioridazine (Mellaril)
ii. benzisoxazole: risperidone (Risperdal)
iii. thioxanthenes: chlorprothixene (Taractan)
iv. butyrophenones: haloperidol (Haldol)
c. use: treatment of psychotic symptoms in schizophrenia, psychosis, Tourette's syndrome, bipolar disorder
d. adverse effects
i. excessive sedation
ii. jaundice
iii. orthostatic hypotension
iv. urinary retention
v. anorexia
vi. dry mouth
vii. hypersensitivity reactions (such as photoallergic reaction, impotence, cardiac toxicity)
viii. blood dyscrasias - agranulocytosis
ix. extrapyramidal side effects: dystonia, pseudoparkinsonism, akathisia, akinesia, tardive dyskinesia
x. neuroleptic malignant syndrome: fever, muscle rigidity, agitation, confusion, deliruim, respiratory failure
e. nursing interventions
i. assess client's response to therapy
ii. monitor for signs of infection, liver toxicity, extrapyramidal symptoms
iii. monitor blood work if long-term therapy
iv. monitor vital signs
v. give medication at bedtime
vi. teach client
• avoid alcohol use
• avoid driving or other hazardous activities
• avoid exposure to direct sunlight
• good oral hygiene
• report extrapyramidal symptoms or signs of infection to physician
• drink plenty of water
b. examples
i. phenothiazines: chlorpromazine (Thorazine), thioridazine (Mellaril)
ii. benzisoxazole: risperidone (Risperdal)
iii. thioxanthenes: chlorprothixene (Taractan)
iv. butyrophenones: haloperidol (Haldol)
c. use: treatment of psychotic symptoms in schizophrenia, psychosis, Tourette's syndrome, bipolar disorder
d. adverse effects
i. excessive sedation
ii. jaundice
iii. orthostatic hypotension
iv. urinary retention
v. anorexia
vi. dry mouth
vii. hypersensitivity reactions (such as photoallergic reaction, impotence, cardiac toxicity)
viii. blood dyscrasias - agranulocytosis
ix. extrapyramidal side effects: dystonia, pseudoparkinsonism, akathisia, akinesia, tardive dyskinesia
x. neuroleptic malignant syndrome: fever, muscle rigidity, agitation, confusion, deliruim, respiratory failure
e. nursing interventions
i. assess client's response to therapy
ii. monitor for signs of infection, liver toxicity, extrapyramidal symptoms
iii. monitor blood work if long-term therapy
iv. monitor vital signs
v. give medication at bedtime
vi. teach client
• avoid alcohol use
• avoid driving or other hazardous activities
• avoid exposure to direct sunlight
• good oral hygiene
• report extrapyramidal symptoms or signs of infection to physician
• drink plenty of water
Antimanic agents
a. action: reduces adrenergic neurotransmitter levels in cerebral tissue
b. examples
i. antimanic agents: lithium carbonate (Lithane)
ii. alternative antimanic agents: carbamazepine (Tegretol), clonazepam (Klonopin)
c. use: control of manic phase of mood disorders; bipolar disorder
d. adverse effects
i. metallic taste
ii. hand tremors
iii. excess voiding and extreme thirst
iv. slurred speech
v. disorientation
vi. cogwheel rigidity
vii. renal failure
viii. respiratory depression
e. nursing interventions
i. monitor blood levels
ii. avoid concurrent administration of adrenergic drugs
iii. evaluate client's response to medication
iv. teach client
• effect of medication may take several weeks
• high intake of fluids and normal sodium
• toxicity signs: diarrhea, vomiting, weak muscles, confusion etc.
• take medication with meals
Antidepressants
a. action: increase norephinephrine at subcortical neuroeffector sites
b. examples
d. adverse effects
i. norepinephrine blockers
• potentiate anticholinergics and CNS depressants
• orthostatic hypotension
• drowsiness, dizziness, confusion
• CNS stimulation
ii. MAOIs
• potentiate alcohol, barbiturates, antihistamines
• hypertensive crisis with ingestion of foods high in tyramine (pickled herring, beer, wine, cheese, chocolate)
• orthostatic hypotension
iii. selective serotonin reuptake inhibitors
• may interact with tryptophan
• insomnia
• headache
• sexual dysfunction
• gastric irritation
e. contraindications
i. acute schizophrenia
ii. mixed mania and depression
iii. suicidal tendencies
iv. narrow angle glaucoma
f. nursing interventions
i. monitor effect of medication
ii. maintain suicide precautions especially as depression lifts
iii. give SSRIs in morning; TCAs at bedtime
iv. teach client
• do not take OTC medication without physician approval
• avoid hazardous activities
• effect of medication may take up to four weeks
• MAOIs: teach client to avoid food containing tyramine; monitor client for hypertensive crisis
• SSRIs and MAOIs should not be given concurrently or close together
b. examples
- i. norepinephrine blockers (tricyclic, TCAs): amitriptyline (Elavil), imipramine (Tofranil)
- ii. monoamine oxidase inhibitors (MAOIs): isocarboxazid (Marplan), phenelzine sulfate (Nardil)
- iii. selective serotonin reuptake inhibitors: fluoxetine (Prozac), sertraline (Zoloft)
d. adverse effects
i. norepinephrine blockers
• potentiate anticholinergics and CNS depressants
• orthostatic hypotension
• drowsiness, dizziness, confusion
• CNS stimulation
ii. MAOIs
• potentiate alcohol, barbiturates, antihistamines
• hypertensive crisis with ingestion of foods high in tyramine (pickled herring, beer, wine, cheese, chocolate)
• orthostatic hypotension
iii. selective serotonin reuptake inhibitors
• may interact with tryptophan
• insomnia
• headache
• sexual dysfunction
• gastric irritation
e. contraindications
i. acute schizophrenia
ii. mixed mania and depression
iii. suicidal tendencies
iv. narrow angle glaucoma
f. nursing interventions
i. monitor effect of medication
ii. maintain suicide precautions especially as depression lifts
iii. give SSRIs in morning; TCAs at bedtime
iv. teach client
• do not take OTC medication without physician approval
• avoid hazardous activities
• effect of medication may take up to four weeks
• MAOIs: teach client to avoid food containing tyramine; monitor client for hypertensive crisis
• SSRIs and MAOIs should not be given concurrently or close together
Cholinesterase inhibitors
a. action
i. prevents breakdown of acetylcholine at nerve endings
ii. facilitates transmission of impulses across myoneural junction
iii. strengthens muscle contractions including respiratory muscles
b. examples
i. edrophonium chloride (Tensilon) for diagnostic purposes
ii. neostigmine bromide (Prostigmin)
iii. ambenonium chloride (Mytelase)
c. use: treat myasthenia gravis
d. adverse effects
i. gastric irritation: nausea, vomiting, diarrhea
ii. hypersalivation
iii. CNS disturbances
iv. orthostatic hypotension
v. toxicity: pulmonary edema, respiratory failure, bronchospasm
e. contraindications
i. intestinal obstruction, renal obstruction
ii. peritonitis
f. nursing interventions
i. monitor client response to medication; may need to adjust dosage
ii. monitor vital signs during period of dosage adjustment
iii. keep atropine sulfate available for overdosage
iv. administer medication with food
v. administer medication as per schedule
vi. teach client
• wear medic alert jewelry and ID
• change position cautiously; sit at first feeling of faintness.
i. prevents breakdown of acetylcholine at nerve endings
ii. facilitates transmission of impulses across myoneural junction
iii. strengthens muscle contractions including respiratory muscles
b. examples
i. edrophonium chloride (Tensilon) for diagnostic purposes
ii. neostigmine bromide (Prostigmin)
iii. ambenonium chloride (Mytelase)
c. use: treat myasthenia gravis
d. adverse effects
i. gastric irritation: nausea, vomiting, diarrhea
ii. hypersalivation
iii. CNS disturbances
iv. orthostatic hypotension
v. toxicity: pulmonary edema, respiratory failure, bronchospasm
e. contraindications
i. intestinal obstruction, renal obstruction
ii. peritonitis
f. nursing interventions
i. monitor client response to medication; may need to adjust dosage
ii. monitor vital signs during period of dosage adjustment
iii. keep atropine sulfate available for overdosage
iv. administer medication with food
v. administer medication as per schedule
vi. teach client
• wear medic alert jewelry and ID
• change position cautiously; sit at first feeling of faintness.
Antiparkinson agents
a. action
i. anticholinergics: block or compete at central acetylcholine receptors
ii. dopamine agonists: activation of dopamine receptors
iii. reinforce client education
• do not stop taking antiparkinsonian meds suddenly: may precipitate parkinsonian crisis
• continue medical supervision
• avoid alcohol while on therapy
• take with meals
• caution with hazardous activities
• to change position slowly to prevent orthostatic hypotension
• levodopa
o minimize Vitamin B6 in diet, because it hinders drug's effectiveness
o do not take OTC medications without health care provider's approval
o sweat and urine may be dark colored
o toxicity: personality changes, increased twitching, grimacing, tongue protrusion
i. anticholinergics: block or compete at central acetylcholine receptors
ii. dopamine agonists: activation of dopamine receptors
iii. reinforce client education
• do not stop taking antiparkinsonian meds suddenly: may precipitate parkinsonian crisis
• continue medical supervision
• avoid alcohol while on therapy
• take with meals
• caution with hazardous activities
• to change position slowly to prevent orthostatic hypotension
• levodopa
o minimize Vitamin B6 in diet, because it hinders drug's effectiveness
o do not take OTC medications without health care provider's approval
o sweat and urine may be dark colored
o toxicity: personality changes, increased twitching, grimacing, tongue protrusion
Anticonvulsants
action :
modifies bioelectric activity at subcortical and cortical areas
examples
adverse effects
i. blood dyscrasias
ii. gastric effects - nausea, vomiting
iii. CNS depression - dizziness, drowsiness
iv. phenytoin: ataxia, hirsutism, hypotension
contraindications
i. hypersensitivity
nursing interventions
i. give medication with food
ii. wiith phenytoin: monitor condition of oral mucosa, don't mix with other IV fluids, monitor blood lab results, monitor urine
iii. renal, liver, and blood studies
iv. teach clients
• avoid alcohol
• notify physician of unusual symptoms
• carry medical alert information
• take medication on schedule; do not discontinue
• avoid driving and other potentially hazardous activities
• phenytoin: good oral hygiene, frequent dental visits
modifies bioelectric activity at subcortical and cortical areas
examples
- i. diazepam (Valium)
- ii. magnesium sulfate
- iii. phenytoin (Dilantin)
- iv. phenobarbital (Luminal)
adverse effects
i. blood dyscrasias
ii. gastric effects - nausea, vomiting
iii. CNS depression - dizziness, drowsiness
iv. phenytoin: ataxia, hirsutism, hypotension
contraindications
i. hypersensitivity
nursing interventions
i. give medication with food
ii. wiith phenytoin: monitor condition of oral mucosa, don't mix with other IV fluids, monitor blood lab results, monitor urine
iii. renal, liver, and blood studies
iv. teach clients
• avoid alcohol
• notify physician of unusual symptoms
• carry medical alert information
• take medication on schedule; do not discontinue
• avoid driving and other potentially hazardous activities
• phenytoin: good oral hygiene, frequent dental visits
Anti-inflammatories
action:
stabilizes mast cells so chemical mediators are not released as easily; decreases bronchial hyperreactivity; decreases airway inflammation
example:
1. cromolyn sodium (Intal)
2. leukotriene receptor antagonists-zafirlukast (Accolate), montelukast (Singular)
3. glucocorticoids- beclamethasone (Vanceril), triamcinolone (Azmacort)
use:
to prevent asthma attacks, exercise-induced bronchospasms
adverse effects
1. cough
2. CNS disturbances
3. burning, stinging eyes
4. throat irritation
5. headache
contraindications
1. status asthmaticus
2. hypersensitivity
nursing interventions
1. monitor eosinophil count
2. monitor respiratory status
3. store in tightly closed light-resistant container; keep cool
4. teach client
* how to use the inhaler
* rinse mouth after using steroid inhaler
* when to call health care provider if medications are not effective
* that therapeutic effect may take up to four weeks
stabilizes mast cells so chemical mediators are not released as easily; decreases bronchial hyperreactivity; decreases airway inflammation
example:
1. cromolyn sodium (Intal)
2. leukotriene receptor antagonists-zafirlukast (Accolate), montelukast (Singular)
3. glucocorticoids- beclamethasone (Vanceril), triamcinolone (Azmacort)
use:
to prevent asthma attacks, exercise-induced bronchospasms
adverse effects
1. cough
2. CNS disturbances
3. burning, stinging eyes
4. throat irritation
5. headache
contraindications
1. status asthmaticus
2. hypersensitivity
nursing interventions
1. monitor eosinophil count
2. monitor respiratory status
3. store in tightly closed light-resistant container; keep cool
4. teach client
* how to use the inhaler
* rinse mouth after using steroid inhaler
* when to call health care provider if medications are not effective
* that therapeutic effect may take up to four weeks
Antihistamines
action:
blocks histamine at receptor sites
examples
1. promethazine HCL (Phenergan)
2. chlorpheniramine maleate (Chlor-Trimeton)
3. diphenhydramine (Benedryl)
uses
1. relieves symptoms of allergies, colds, pruritus
2. prevents problems in blood transfusion and drug reactions
adverse effects
1. drowsiness
2. gastric effects
3. dry mouth
4. headache
5. thickening of bronchial secretions
contraindications
1. acute asthma
2. lower respiratory heart disease
3. narrow angle glaucoma
nursing interventions
1. discontinue four days before skin testing for allergies
2. avoid interaction with CNS depressants
3. teach client
* avoid driving and hazardous activities
* take antihistamines with food
* additive effect with alcohol, other CNS depressants
blocks histamine at receptor sites
examples
1. promethazine HCL (Phenergan)
2. chlorpheniramine maleate (Chlor-Trimeton)
3. diphenhydramine (Benedryl)
uses
1. relieves symptoms of allergies, colds, pruritus
2. prevents problems in blood transfusion and drug reactions
adverse effects
1. drowsiness
2. gastric effects
3. dry mouth
4. headache
5. thickening of bronchial secretions
contraindications
1. acute asthma
2. lower respiratory heart disease
3. narrow angle glaucoma
nursing interventions
1. discontinue four days before skin testing for allergies
2. avoid interaction with CNS depressants
3. teach client
* avoid driving and hazardous activities
* take antihistamines with food
* additive effect with alcohol, other CNS depressants
Antituberculosis agents
action:
appears to inhibit RNA synthesis, so stops tubercle bacilli from multiplying (first line) or functioning (second line)
examples
1. first line
* ethambutol (Myambutol) decreases mycobacterial RNA synthesis
* isoniazid (INH) - suppresses mycobacterial cell-wall synthesis
2. second line
* capreomycin (Capastat)
* pyrazinamide (PZA)
adverse effects
1. gastric irritation
2. CNS disturbances
3. liver disturbances
4. blood dyscrasias
5. streptomycin - ototoxicity
6. ethambutol - visual disturbances
7. isoniazid - suppressed absorption of fat and vitamin B complex
contraindications
1. severe renal disease
2. hypersensitivity
nursing interventions
1. monitor client response to therapy
2. monitor blood work during therapy
3. if CNS disturbances are evident, take safety precautions
4. teach client
* to take medication as ordered
* to eat foods rich in B-complex vitamins
* avoid use of alcohol
* report if become pregnant
* ethambutol: report eye problems, have regular eye exams
appears to inhibit RNA synthesis, so stops tubercle bacilli from multiplying (first line) or functioning (second line)
examples
1. first line
* ethambutol (Myambutol) decreases mycobacterial RNA synthesis
* isoniazid (INH) - suppresses mycobacterial cell-wall synthesis
2. second line
* capreomycin (Capastat)
* pyrazinamide (PZA)
adverse effects
1. gastric irritation
2. CNS disturbances
3. liver disturbances
4. blood dyscrasias
5. streptomycin - ototoxicity
6. ethambutol - visual disturbances
7. isoniazid - suppressed absorption of fat and vitamin B complex
contraindications
1. severe renal disease
2. hypersensitivity
nursing interventions
1. monitor client response to therapy
2. monitor blood work during therapy
3. if CNS disturbances are evident, take safety precautions
4. teach client
* to take medication as ordered
* to eat foods rich in B-complex vitamins
* avoid use of alcohol
* report if become pregnant
* ethambutol: report eye problems, have regular eye exams
Antitussives
action:
to supress coughs through medullary cough center or indirect action on sensory nerves
examples
1. narcotic: codeine, hydrocodone bitartrate (Hycoda)
2. nonnarcotic - dextromethorphan (Robitussin)
use:
colds, respiratory congestion, pneumonia, bronchitis, TB, cystic fibrosis, emphysema
adverse effects
1. drowsiness
2. nausea
3. dry mouth
4. dizziness
contraindications
1. hypothyroidism
2. iodine sensitivity
nursing interventions
1. monitor blood counts with long term therapy
2. increase fluid intake
3. humidify client's room
4. teach client
* increase fluid intake if not contraindicated
* do not to take fluids immediately after medication
* avoid driving and other hazardous activity especially if taking narcotic type
* antitussives add to the effects of alcohol
to supress coughs through medullary cough center or indirect action on sensory nerves
examples
1. narcotic: codeine, hydrocodone bitartrate (Hycoda)
2. nonnarcotic - dextromethorphan (Robitussin)
use:
colds, respiratory congestion, pneumonia, bronchitis, TB, cystic fibrosis, emphysema
adverse effects
1. drowsiness
2. nausea
3. dry mouth
4. dizziness
contraindications
1. hypothyroidism
2. iodine sensitivity
nursing interventions
1. monitor blood counts with long term therapy
2. increase fluid intake
3. humidify client's room
4. teach client
* increase fluid intake if not contraindicated
* do not to take fluids immediately after medication
* avoid driving and other hazardous activity especially if taking narcotic type
* antitussives add to the effects of alcohol
Mucolytics/expectorants
action
1. mucolytics: disrupt molecular bonds and thins mucus
2. expectorants: stimulate a gastric mucosal reflex to increase production of lung mucous
examples
1. mucolytic: acetylcysteine (Mucomyst)
2. expectorant: guaifenesin (Robitussin)
uses
1. asthma
2. acute or chronic bronchopulmonary disease
3. cystic fibrosis
4. mucomyst: acetaminophen toxicity
adverse side effects
1. oropharyngeal irritation
2. bronchospasm
3. gastric effects
contraindications
1. increased intracranial pressure
2. status asthmaticus
nursing interventions
1. monitor respiratory status
2. teach client
* take no fluids directly after oral administration
* do take plenty of fluids
* encourage coughing and deep breathing, especially before treatment
1. mucolytics: disrupt molecular bonds and thins mucus
2. expectorants: stimulate a gastric mucosal reflex to increase production of lung mucous
examples
1. mucolytic: acetylcysteine (Mucomyst)
2. expectorant: guaifenesin (Robitussin)
uses
1. asthma
2. acute or chronic bronchopulmonary disease
3. cystic fibrosis
4. mucomyst: acetaminophen toxicity
adverse side effects
1. oropharyngeal irritation
2. bronchospasm
3. gastric effects
contraindications
1. increased intracranial pressure
2. status asthmaticus
nursing interventions
1. monitor respiratory status
2. teach client
* take no fluids directly after oral administration
* do take plenty of fluids
* encourage coughing and deep breathing, especially before treatment
Bronchodilators
action:
1. dilate air passages in the lungs, specific action dependent on type of drug.
2. increase heart rate
3. act on the autonomic nervous system
examples
1. beta-adrenergic: abuterol (Proventil, Ventolin), metaproterenol (Alupent)
2. xanthines: aminophylline, theophylline (Theo-Dur) acts on bronchial smooth muscle
3. epinephrine HCL (Adrenalin) - increases the rate and strength of cardiac contraction through the sympathetic nervous system
4. isoproterenol HCL (Isuprel) - increases the heart rate by stimulating the beta-adrenergic blocking agent of the sympathetic nervous system
use
1. bronchospasms
2. asthma
adverse effects
1. dizziness
2. tremors
3. anxiety
4. palpitations
5. gastric disturbances
6. headache
7. tachycardia
8. dysrhythmias
contraindications
1. hypersensitivity
2. narrow angle glaucoma
3. tachydysrhythmias
4. severe cardiac disease
nursing interventions
1. monitor theophylline levels (normal ten to 20 mcg/dl)
2. monitor intake and output, and vital signs
3. monitor EKG, vital signs during therapy
4. teach clients
* take medication as prescribed only
* report adverse effects
* stop smoking during therapy
* take with meals
* avoid OTC drugs
1. dilate air passages in the lungs, specific action dependent on type of drug.
2. increase heart rate
3. act on the autonomic nervous system
examples
1. beta-adrenergic: abuterol (Proventil, Ventolin), metaproterenol (Alupent)
2. xanthines: aminophylline, theophylline (Theo-Dur) acts on bronchial smooth muscle
3. epinephrine HCL (Adrenalin) - increases the rate and strength of cardiac contraction through the sympathetic nervous system
4. isoproterenol HCL (Isuprel) - increases the heart rate by stimulating the beta-adrenergic blocking agent of the sympathetic nervous system
use
1. bronchospasms
2. asthma
adverse effects
1. dizziness
2. tremors
3. anxiety
4. palpitations
5. gastric disturbances
6. headache
7. tachycardia
8. dysrhythmias
contraindications
1. hypersensitivity
2. narrow angle glaucoma
3. tachydysrhythmias
4. severe cardiac disease
nursing interventions
1. monitor theophylline levels (normal ten to 20 mcg/dl)
2. monitor intake and output, and vital signs
3. monitor EKG, vital signs during therapy
4. teach clients
* take medication as prescribed only
* report adverse effects
* stop smoking during therapy
* take with meals
* avoid OTC drugs
Antidysrhythmics
1. action
3. use: to treat abnormalities in cardiac rate and rhythm
4. adverse effects
1. monitor cardiac rhythm
2. monitor blood levels
3. monitor for blood dyscrasias
4. administer oral preparations with meals
5. monitor EKGs
6. use infusion-control devices for IV administration
7. teach client
* report changes in heart rate and/or rhythm
report any side effects
- 1. prevent abnormal heart rhythms
- 2. action depends on type of antidysrhythmics drug
- 1. class I: sodium channel blockers - quinidine (Quinidex), lidocaine; decreases myocardial excitability and contractility
- 2. class II: beta blockers -propranolol (Inderal); stabilizes cell membrane
- 3. class III: conduction delayers- bretylium (Bretylol); decreases conduction and excitability of myocardial cells
- 4. class IV: calcium channel blockers - verapamil (Isoptin);inhibits influx of calcium ions across cell membrane during cardiac contraction; reduces cardiac excitability and dilates main coronary arteries
- 5. others - digoxin (Lanoxin), adenosine (Adenocard); slows heart rate, improves pumping ability of the heart
3. use: to treat abnormalities in cardiac rate and rhythm
4. adverse effects
- 1. hypotension
- 2. nausea and vomiting
- 3. blood dyscrasias
- 4. toxicity such as CNS disturbances due to neurotoxicity, and diarrhea due to GI irritation
1. monitor cardiac rhythm
2. monitor blood levels
3. monitor for blood dyscrasias
4. administer oral preparations with meals
5. monitor EKGs
6. use infusion-control devices for IV administration
7. teach client
* report changes in heart rate and/or rhythm
report any side effects
Anticoagulants
1. action: disrupt the blood coagulation process, thereby suppressing the production of fibrin
2. examples
1. heparin: monitor APTT (activated partial thromboplastin time)
* normal 40 seconds
* at therapeutic levels, APTT increases by a factor of 1.5 to 2
2. coumadin - monitor PT (prothrombin time)
* normal 12 seconds
* INR (International normalized ratio) two to three
3. do baseline blood studies before therapy
4. have antidote ready
* heparin: protamine sulfate
* coumadin: vitamin K
5. monitor client for symptoms of hemorrhage such as increased pulse, decreased BP
6. avoid salicylates (such as aspirin)
7. avoid IM injections
8. teach client
* take medication at same time every day
* wear medical alert jewelry: wearer takes anticoagulants (illustration )
* use a soft toothbrush
* do not use a straight razor; use an electric razor
* avoid alcohol and smoking
* report any signs of bleeding, red or black bowel movements, headaches, rashes, red or pink-tinged urine, sputum
* avoid trauma
* blood levels of the anticoagulant may be monitored
* do not take over-the-counter (OTC) medications without health care provider's approval
2. examples
- 1. heparin: parenteral administration
- 2. coumadin (Warfarin): oral administration
- 1. pulmonary embolism
- 2. deep vein thrombosis
- 3. myocardial infarction
- 4. atrial fibrillation
- 1. allergic responses such as chills, fever and urticaria
- 2. use cautiously if client tends to bleed (hemophilia, peptic ulcer)
- 3. GI disturbances- nausea and vomiting, diarrhea, abdominal cramps
- 1. hemophilia
- 2. leukemia
- 3. peptic ulcer
- 4. blood dyscrasias
1. heparin: monitor APTT (activated partial thromboplastin time)
* normal 40 seconds
* at therapeutic levels, APTT increases by a factor of 1.5 to 2
2. coumadin - monitor PT (prothrombin time)
* normal 12 seconds
* INR (International normalized ratio) two to three
3. do baseline blood studies before therapy
4. have antidote ready
* heparin: protamine sulfate
* coumadin: vitamin K
5. monitor client for symptoms of hemorrhage such as increased pulse, decreased BP
6. avoid salicylates (such as aspirin)
7. avoid IM injections
8. teach client
* take medication at same time every day
* wear medical alert jewelry: wearer takes anticoagulants (illustration )
* use a soft toothbrush
* do not use a straight razor; use an electric razor
* avoid alcohol and smoking
* report any signs of bleeding, red or black bowel movements, headaches, rashes, red or pink-tinged urine, sputum
* avoid trauma
* blood levels of the anticoagulant may be monitored
* do not take over-the-counter (OTC) medications without health care provider's approval
Hypotension and shock
1. natural and synthetic catecholamines
2. examples: epinephrine, dopamine (Intropin), dobutamine (Dobutrex)
3. actions: increase cardiac output, (+) inotrope, (+) chronotrope
4. uses: dopamine and dobutamine: hypovolemic and cardiogenic shock, epinephrine: anaphylactic shock
5. adverse effects: dysrhythmias, hypotension, tissue necrosis if extravasation occurs. Tremors, anxiety, dizziness with epinephrine
6. contraindications
1. hypersensitivity
2. ventricular fibrillation
3. tachydysrhythmias
4. safety in children not known
7. nursing interventions
1. correct hypokalemia before administering
2. monitor vital signs frequently
3. monitor ECG continuously during administration
4. administer with infusion pump
5. start drug slowly and increase according to health care provider's orders
6. monitor injection site for extravasation
7. protect solution from light
8. do not use discolored solution
9. stop the drug gradually
2. examples: epinephrine, dopamine (Intropin), dobutamine (Dobutrex)
3. actions: increase cardiac output, (+) inotrope, (+) chronotrope
4. uses: dopamine and dobutamine: hypovolemic and cardiogenic shock, epinephrine: anaphylactic shock
5. adverse effects: dysrhythmias, hypotension, tissue necrosis if extravasation occurs. Tremors, anxiety, dizziness with epinephrine
6. contraindications
1. hypersensitivity
2. ventricular fibrillation
3. tachydysrhythmias
4. safety in children not known
7. nursing interventions
1. correct hypokalemia before administering
2. monitor vital signs frequently
3. monitor ECG continuously during administration
4. administer with infusion pump
5. start drug slowly and increase according to health care provider's orders
6. monitor injection site for extravasation
7. protect solution from light
8. do not use discolored solution
9. stop the drug gradually
calcium channel blockers
1. examples: verapamil (Isoptin), nifedipine (Adalat), diltiazem (Cardizem)
2. action: prevent the movement of extracellular calcium into the cell resulting in coronary and peripheral artery dilation
3. uses: stable angina, dysrhythmias, hypertension
4. side effects: headache, drowsiness, dizziness, GI disturbances, flushing of the skin
5. contraindications: hypersensitivity
6. nursing interventions
* monitor chest pain
* monitor ECG if used for dysrhythmia
* administer with food
* instruct client
o increase fluids to counteract constipation
o take pulse before taking drug
o avoid hazardous activities until stabilized on drug
o limit caffeine consumption
o avoid alcohol
o change position slowly
2. action: prevent the movement of extracellular calcium into the cell resulting in coronary and peripheral artery dilation
3. uses: stable angina, dysrhythmias, hypertension
4. side effects: headache, drowsiness, dizziness, GI disturbances, flushing of the skin
5. contraindications: hypersensitivity
6. nursing interventions
* monitor chest pain
* monitor ECG if used for dysrhythmia
* administer with food
* instruct client
o increase fluids to counteract constipation
o take pulse before taking drug
o avoid hazardous activities until stabilized on drug
o limit caffeine consumption
o avoid alcohol
o change position slowly
beta-adrenergic blocking agents
1. examples: propranolol (Inderal), metoprolol (Lopressor)
2. action: inhibit sympathetic stimulation of beta receptors in the heart decreases heart rate and force of myocardial contraction thus decreasing myocardial oxygen consumption
3. uses: reduces frequency and severity of acute anginal attacks, dysrhythmias
4. side effects: blood dyscrasias, hypotension, GI disturbances, flushing of the skin
5. contraindications
* hypersensitivity
* cardiogenic shock
* cardiac failure
6. nursing interventions
* weigh daily. Report weight gain of five pounds or greater
* monitor ECG if using for dysrhythmia
* administer on an empty stomach
* protect injectable solution from light
* instruct client
o take pulse before taking drug
o not to discontinue medication abruptly
o avoid hazardous activities if drowsiness occurs
o make position changes slowly
o take drug at same time each day
2. action: inhibit sympathetic stimulation of beta receptors in the heart decreases heart rate and force of myocardial contraction thus decreasing myocardial oxygen consumption
3. uses: reduces frequency and severity of acute anginal attacks, dysrhythmias
4. side effects: blood dyscrasias, hypotension, GI disturbances, flushing of the skin
5. contraindications
* hypersensitivity
* cardiogenic shock
* cardiac failure
6. nursing interventions
* weigh daily. Report weight gain of five pounds or greater
* monitor ECG if using for dysrhythmia
* administer on an empty stomach
* protect injectable solution from light
* instruct client
o take pulse before taking drug
o not to discontinue medication abruptly
o avoid hazardous activities if drowsiness occurs
o make position changes slowly
o take drug at same time each day
Nitrates
1. examples: nitroglycerin, isosorbide dinitrate (Isordil)
2. action: dilate arterioles which lowers peripheral vascular resistance (afterload)
3. uses: treatment and prevention of acute chest pain caused by myocardial ischemia
4. adverse effects: postural hypotension, headache, flushing, dizziness
5. contraindications
* hypersensitivity
* severe anemia
* hypotension
* hypovolemia
6. nursing Interventions
* monitor for orthostatic hypotension
* monitor for tolerance with long term use
* administer every five minutes but not more than three tablets in 15 minutes
* if pain not relieved after 15 minutes and three tablets, notify physician immediately
* instruct client
o take pulse before taking medication
o take oral preparations without food
o when to seek medical attention
o not to chew or swallow sublingual tabs
o make position changes slowly
o carry drug so that it is always within reach but avoid exposure to body heat and light
o replace drug approximately every six months
o avoid alcohol ingestion
2. action: dilate arterioles which lowers peripheral vascular resistance (afterload)
3. uses: treatment and prevention of acute chest pain caused by myocardial ischemia
4. adverse effects: postural hypotension, headache, flushing, dizziness
5. contraindications
* hypersensitivity
* severe anemia
* hypotension
* hypovolemia
6. nursing Interventions
* monitor for orthostatic hypotension
* monitor for tolerance with long term use
* administer every five minutes but not more than three tablets in 15 minutes
* if pain not relieved after 15 minutes and three tablets, notify physician immediately
* instruct client
o take pulse before taking medication
o take oral preparations without food
o when to seek medical attention
o not to chew or swallow sublingual tabs
o make position changes slowly
o carry drug so that it is always within reach but avoid exposure to body heat and light
o replace drug approximately every six months
o avoid alcohol ingestion
Lipid-lowering agents (antilipemic)
action and use: lower LDL levels by reducing the synthesis of cholesterol and/or triglycerides. Use: primary hypercholesterolemia
examples
1. cholestyramine (Questran)
2. atorvastatin (Lipitor)
3. colestipol (Colestid)
4. nicotinic acid (Niacin)
contraindications:
1. hypersensitivity
2. pregnancy/lactation
3. active liver disease
adverse side effects
1. skin flushing
2. gastric upset
3. niacin: temporary, intense flushing of face, neck and ears
4. reduced absorption of fat-soluble vitamins
5. disruption of liver function
6. muscle tenderness or weakness (rhabdomyolysis)
nursing interventions
1. monitor cholesterol levels
2. monitor liver function tests
3. teach client
* blood work and eye exams will be necessary during treatment
* to report blurred vision, severe GI symptoms, or headache
* about low-cholesterol high-fiber diet
* to report muscle weakness or tenderness
4. with cholestyramine, colestipol: Give other medications (e.g., such as thiazide diuretics, digoxin, warfarin, and certain antibiotics) one hour before or four hours after administration of cholestryramine and colestipol, so that they will not react with bile-acid-binding resins
examples
1. cholestyramine (Questran)
2. atorvastatin (Lipitor)
3. colestipol (Colestid)
4. nicotinic acid (Niacin)
contraindications:
1. hypersensitivity
2. pregnancy/lactation
3. active liver disease
adverse side effects
1. skin flushing
2. gastric upset
3. niacin: temporary, intense flushing of face, neck and ears
4. reduced absorption of fat-soluble vitamins
5. disruption of liver function
6. muscle tenderness or weakness (rhabdomyolysis)
nursing interventions
1. monitor cholesterol levels
2. monitor liver function tests
3. teach client
* blood work and eye exams will be necessary during treatment
* to report blurred vision, severe GI symptoms, or headache
* about low-cholesterol high-fiber diet
* to report muscle weakness or tenderness
4. with cholestyramine, colestipol: Give other medications (e.g., such as thiazide diuretics, digoxin, warfarin, and certain antibiotics) one hour before or four hours after administration of cholestryramine and colestipol, so that they will not react with bile-acid-binding resins
Thrombolytics
action: binds with plasminogen to dissolve thrombi (clots) in coronary arteries within four to six hours of myocardial infarction. Activates conversion of plasminogen to plasmin. Plasmin is able to break down clots (fibrin).
examples
1. streptokinase (Streptase)
2. urokinase (Abbokinase)
uses
1. myocardial infarction
2. deep venous thrombosis
3. pulmonary emboli
contraindications
1. active bleeding
2. cerebral embolism/thrombosis/hemorrhage
3. recent intraarterial diagnostic procedure or surgery
4. recent major surgery
5. neoplasms of the CNS
6. severe hypertension
adverse side effects
1. bleeding
2. allergic reactions:urticaria, itching, flushing, headache (illustration )
nursing interventions
examples
1. streptokinase (Streptase)
2. urokinase (Abbokinase)
uses
1. myocardial infarction
2. deep venous thrombosis
3. pulmonary emboli
contraindications
1. active bleeding
2. cerebral embolism/thrombosis/hemorrhage
3. recent intraarterial diagnostic procedure or surgery
4. recent major surgery
5. neoplasms of the CNS
6. severe hypertension
adverse side effects
1. bleeding
2. allergic reactions:urticaria, itching, flushing, headache (illustration )
nursing interventions
- monitor for bleeding
- monitor coagulation studies
- monitor for allergic reactions
- keep available: aminocaproic acid (fibrinolysis inhibitor)
Antihypertensives
1. action: dilates peripheral blood vessels
2. examples
Many hypertensives have trade names that contain –vas- -pres- -pas-
3. use: hypertension
4. contraindications
1. monitor vital signs and blood pressure, sitting and standing
2. monitor for hearing changes, renal functioning
3. if hypotension, closely monitor client
4. encourage intake of foods high in vitamin B
5. teach client
* low sodium diet
* change positions slowly
* take medication as instructed
* avoid hazardous activities
* protect medication from heat and light
2. examples
- 1. hydralazine HCL (Apresoline)
- 2. enalapril maleate (Vasotec)
- 3. reserpine (Serpasil)
- 4. prazosin HCL (Minipress)
- 5. methyldopa (Aldomet)
- 6. clonidine (Catapres)
Many hypertensives have trade names that contain –vas- -pres- -pas-
3. use: hypertension
4. contraindications
- 1. heart block
- 2. children
- 1. orthostatic hypotension
- 2. dizziness
- 3. bradycardia
- 4. tachycardia
- 5. sexual dysfunction
- 6. deterioration in renal function
- 7. agranulosis
1. monitor vital signs and blood pressure, sitting and standing
2. monitor for hearing changes, renal functioning
3. if hypotension, closely monitor client
4. encourage intake of foods high in vitamin B
5. teach client
* low sodium diet
* change positions slowly
* take medication as instructed
* avoid hazardous activities
* protect medication from heat and light
Cardiac glycosides
1. action: makes heart beat slower but stronger
1. before giving glycoside, check apical pulse and heart rhythm. Report if <>
2. establish baseline data such as vital signs, electrolytes, clinical symptoms, creatinine clearance test
3. monitor for drug toxicity
* in children - cardiac arrhythmias
* in adults - visual disturbances, nausea and vomiting, anorexia
* older clients more prone to toxicity
4. monitor drug levels
* therapeutic range 0.8 to 2.0 ng/ml
* toxic range > two ng/ml
* diuretics may increase chance of toxicity
7. monitor intake and output
8. client teaching
1. take medication as prescribed
2. teach client how to take and record pulse daily
3. identify and report signs of toxicity
* for atrial fibrillation: take pulse and report if below 60 or above 100 or changes in rhythm
* daily weights: report two pound increase
- 1. improves pumping ability of heart
- 2. increases force of heart's contraction
- 3. decreases rate of contraction
- 4. increases cardiac output
- 1. digitoxin (Crystodigin)
- 2. digoxin (Lanoxin)
- 1. congestive heart failure
- 2. atrial flutter
- 3. atrial fibrillation
- 1. ventricular tachycardia
- 2. ventricular fibrillation
- 3. second and third degree heart block
- 1. gastrointestinal effects such as nausea and vomiting, diarrhea, and anorexia
- 2. bradycardia
- 3. xanthopsia
- 4. muscle weakness
- 5. dysrhythmia
1. before giving glycoside, check apical pulse and heart rhythm. Report if <>
2. establish baseline data such as vital signs, electrolytes, clinical symptoms, creatinine clearance test
3. monitor for drug toxicity
* in children - cardiac arrhythmias
* in adults - visual disturbances, nausea and vomiting, anorexia
* older clients more prone to toxicity
4. monitor drug levels
* therapeutic range 0.8 to 2.0 ng/ml
* toxic range > two ng/ml
* diuretics may increase chance of toxicity
7. monitor intake and output
8. client teaching
1. take medication as prescribed
2. teach client how to take and record pulse daily
3. identify and report signs of toxicity
* for atrial fibrillation: take pulse and report if below 60 or above 100 or changes in rhythm
* daily weights: report two pound increase
Antigout agents
action: increases excretion of uric acid and decreases uric acid formation
examples
adverse effects:
examples
- i. allopurinol (Zyloprim)
- ii. colchicine (Novocolchine)
- iii. probenecid (Benemid)
adverse effects:
- i. gastric effects: nausea and vomiting, indigestion
- ii. blood dyscrasias
- iii. liver damage
- iv. skin rash
- v. gi disturbances
- nursing interventions
- i. increase fluid intake to prevent renal calculi
- ii. monitor fluid intake and output
- iii. administer with meals
- iv. monitor blood work, including serum uric levels, and electrolyte levels
- v. instruct client
- • lose weight if needed
- • avoid high purine foods (organ meats, sardines, shellfish, etc.)
- • avoid fermented beverages such as beer, ale, wine
Nonsteroidal antinflammatory drugs (NSAIDS)
action: interferes with prostaglandin synthesis
examples: ibuprofen (Motrin), indomethacin (Indocin)
adverse effects
i. administer one hour before or two hours after meals
ii. monitor blood work, vital signs
iii. monitor response to medication
examples: ibuprofen (Motrin), indomethacin (Indocin)
- i. first generation (COX-1 inhibitor) - salicylates (aspirin - Bayer, Ecotrin), ibuprofen(Motrin, Advil), naproxen (Naprosyn)
- ii. second generation (COX-2 inhibitor)- celecoxib (Celebrex)
adverse effects
- i. gastric disturbances- lessened with administration of COX-2 inhibitors
- ii. skin rash
- iii. blood dyscrasias/bleeding
- iv. CNS disturbances
- v. nephrotoxicity
- i. hypersensitivity
- ii. asthma
- iii. renal disease
- iv. liver disease
i. administer one hour before or two hours after meals
ii. monitor blood work, vital signs
iii. monitor response to medication
Skeletal muscle relaxants
use: relax muscles, treat spasm disorders
examples:Baclofen (Lioresal),Carisoprodol (Soma), chlorphenesin (Maolate), chlorzoxazone (Paraflex), cyclobenzaprine (Flexeril), diazepam (Valium), metaxalone (Skelaxin), methocarbamol (Robaxin), and orphenadrine (Norflex)
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