a. action: interferes with several bacterial enzyme systems
b. example
i. nitrofurantoin (Furadantin)
ii. methenamine (Hiprex)
c. use: treat pyelonephritis, pyelitis, cystitis
d. adverse effects
i. anorexia
ii. nausea and vomiting
iii. methenamine - crystalluria, bladder irritation
iv. nitrofurantoin: exfoliative dermatitis, interstitial nephritis, necrosis
e. contraindications
i. hypersensitivity
ii. anuria
iii. severe renal disease
iv. infants < 1 month-old
f. nursing interventions
i. monitor intake and output
ii. teach client
• take medication as prescribed
• drink plenty of fluids
• take medication with food or milk
• with nitrofurantoin:
o do not crush pill because it stains teeth; dilute oral suspensions and rinse mouth after taking
o report changes in urinary pattern
o report muscle weakness, tingling or numbness
o urine may look brown or rust yellow
o avoid alcohol
Bullets
Immunosuppressants
a. action: inhibit immune responses
b. example: cyclosporine (Sandimmune)
c. use
i. prevent organ rejection in transplant patient
ii. treat autoimmune disorders (such as rheumatoid arthritis, systemic lupus erythematosus)
d. adverse effects
i. nephrotoxicity (poisons kidneys)
ii. infection
iii. hypertension
iv. tremor
v. hirsutism
e. contraindications
i. hypersensitivity
ii. nursing interventions
• monitor BUN and creatinine; liver function tests
• teach client
o report early signs of infection (such as fever, sore throat)
o medication may be taken with meals
o take medication same time each day
o hirsutism is reversible when treatment stop
b. example: cyclosporine (Sandimmune)
c. use
i. prevent organ rejection in transplant patient
ii. treat autoimmune disorders (such as rheumatoid arthritis, systemic lupus erythematosus)
d. adverse effects
i. nephrotoxicity (poisons kidneys)
ii. infection
iii. hypertension
iv. tremor
v. hirsutism
e. contraindications
i. hypersensitivity
ii. nursing interventions
• monitor BUN and creatinine; liver function tests
• teach client
o report early signs of infection (such as fever, sore throat)
o medication may be taken with meals
o take medication same time each day
o hirsutism is reversible when treatment stop
Sulfonamides
a. action: substitutes a false metabolite for p-aminobenzoic acid, which is essential for the bacterial synthesis of folic acid
b. example
i. succinylsulfathiazole (Sulfasuxidine)
ii. sulfisoxazole (Gantrisin)
iii. sulfamethoxazole and trimethoprim (Bactrim, Septra)
c. use: urinary tract infections
d. adverse effects
i. gastric irritation: nausea and vomiting, stomatitis
ii. rash
iii. malaise
iv. blood dyscrasias
v. crystalluria
vi. photosensitivity
vii. allergic response
e. contraindications
i. hypersensitivity
ii. infants
Diuretics
a. action: interferes with sodium reabsorption
b. examples
i. loop diuretics interrupt the transport of sodium ions in Loop of Henle
• bumetanide (Bumex)
• furosemide (Lasix)
ii. potassium sparers act on collecting tubules to promote sodium and water excretion
• spironolactone (Aldactone)
• triamterene (Dyrenium)
iii. thiazides: inhibit reabsorption of Na+ and CL- in early distal tubule
• chlorothiazide (Diuril)
• hydrochlorothiazide (Hydrodiuril)
iv. osmotic: increase osmotic pressure of glomerular filtrate
• mannitol
• urea
c. use: treat hypertension, edema
d. adverse side effects
i. gastrointestinal irritation
ii. electrolyte imbalance: hyponatremia, hypokalemia
iii. orthostatic hypotension
iv. dehydration
e. contraindications
i. electrolyte imbalances
ii. dehydration
iii. anuria
f. nursing interventions
i. monitor weight, intake and output, vital signs
ii. give medication in morning
iii. monitor client for fluid and electrolyte imbalance
iv. teach client
• change positions slowly
• report changes in hearing
• diabetic clients: closely monitor glucose levels
b. examples
i. loop diuretics interrupt the transport of sodium ions in Loop of Henle
• bumetanide (Bumex)
• furosemide (Lasix)
ii. potassium sparers act on collecting tubules to promote sodium and water excretion
• spironolactone (Aldactone)
• triamterene (Dyrenium)
iii. thiazides: inhibit reabsorption of Na+ and CL- in early distal tubule
• chlorothiazide (Diuril)
• hydrochlorothiazide (Hydrodiuril)
iv. osmotic: increase osmotic pressure of glomerular filtrate
• mannitol
• urea
c. use: treat hypertension, edema
d. adverse side effects
i. gastrointestinal irritation
ii. electrolyte imbalance: hyponatremia, hypokalemia
iii. orthostatic hypotension
iv. dehydration
e. contraindications
i. electrolyte imbalances
ii. dehydration
iii. anuria
f. nursing interventions
i. monitor weight, intake and output, vital signs
ii. give medication in morning
iii. monitor client for fluid and electrolyte imbalance
iv. teach client
• change positions slowly
• report changes in hearing
• diabetic clients: closely monitor glucose levels
Antidiuretic hormone
a. action: helps distal renal tubules reabsorb water
b. examples
i. lypressin (Diapid)
ii. vasopressin (Pitressin)
c. use: treatment of diabetes insipidus
d. adverse effects
i. gastric disturbances
ii. hyponatremia
iii. water intoxication
iv. cardiac disturbances
e. nursing interventions
i. monitor response to therapy: intake and output, blood pressure
ii. assess for dehydration
Anterior pituitary: growth hormone
a. action: stimulates the growth of practically all organs and tissues
b. examples
i. somatrem (Protropin)
ii. somatropin (Humatrope)
c. use: treat dwarfism
d. adverse effects
i. hyperglycemia
ii. hypothyroidism
iii. antibodies to growth hormone
iv. interaction with glucocorticoids
e. contraindications:
i. hypersensitivity to benzyl alcohol
ii. closed epiphyses
iii. intracranial lesions
f. nursing interventions
i. monitor diabetic client closely
ii. instruct client
• record height measurements at regular intervals
• report to physician if growth is less than expected
Hyperthyroid agents
a. action: blocks synthesis of thyroid hormone
b. examples
i. iodine (Lugol's solution)
ii. methimazole (Tapazole)
iii. propylthiouracil (PTL)
c. use: treat hyperthyroidism
d. adverse effects
i. agranulocytosis
ii. skin disturbances
iii. decreased metabolism
iv. gastric disturbances
v. iodine: stains teeth, bitter taste
e. contraindications:
i. hypersensitivity
f. nursing interventions
i. administer iodine preparations through a straw
ii. monitor effects of medication
iii. instruct client
• report side effects
• avoid OTC drugs containing iodine
• do not discontinue medication abruptly
• carry medic alert jewelry
b. examples
i. iodine (Lugol's solution)
ii. methimazole (Tapazole)
iii. propylthiouracil (PTL)
c. use: treat hyperthyroidism
d. adverse effects
i. agranulocytosis
ii. skin disturbances
iii. decreased metabolism
iv. gastric disturbances
v. iodine: stains teeth, bitter taste
e. contraindications:
i. hypersensitivity
f. nursing interventions
i. administer iodine preparations through a straw
ii. monitor effects of medication
iii. instruct client
• report side effects
• avoid OTC drugs containing iodine
• do not discontinue medication abruptly
• carry medic alert jewelry
Hypothyroid agents
a. action: help regulate the metabolic rate of cells
b. examples
i. levothyroxine sodium (Synthroid)
ii. thyroglobulin (Proloid)
iii. thyroid (Thyrar)
c. use: replace thyroid hormones
d. adverse reactions
i. hyperactivity
ii. cardiac stimulation
iii. thyroid storm
e. contraindications
i. adrenal insufficiency
ii. myocardial infarction
iii. thyrotoxicosis
iv. hypersensitivity to beef
f. nursing interventions
i. monitor client's response to medication
ii. teach client
• usually lifelong therapy
• take medication same time each day
• monitor pulse rate; report pulse rate over 100
• report signs of toxicity (such as chest pain, palpitations, nervousness)
• wear medic alert jewelry / ID
• avoid OTC medications unless approved by health care provider
• continue medical supervision
b. examples
i. levothyroxine sodium (Synthroid)
ii. thyroglobulin (Proloid)
iii. thyroid (Thyrar)
c. use: replace thyroid hormones
d. adverse reactions
i. hyperactivity
ii. cardiac stimulation
iii. thyroid storm
e. contraindications
i. adrenal insufficiency
ii. myocardial infarction
iii. thyrotoxicosis
iv. hypersensitivity to beef
f. nursing interventions
i. monitor client's response to medication
ii. teach client
• usually lifelong therapy
• take medication same time each day
• monitor pulse rate; report pulse rate over 100
• report signs of toxicity (such as chest pain, palpitations, nervousness)
• wear medic alert jewelry / ID
• avoid OTC medications unless approved by health care provider
• continue medical supervision
Antidiabetic agents
a. action: provides insulin to promote transport of glucose; exact mechanism dependent on type of antidiabetic agent
b. examples
i. oral hypoglycemics stimulate pancreatic beta cells to produce insulin tolazamide (Tolinase), glipizide (Glucotrol), metformin (Glucophage), rosiglitazone (Avandia)
ii. parenteral agents provide exogenous insulin
c. use: treat diabetes mellitus
d. adverse effects
i. hypoglycemia, irritability, confusion
ii. convulsions, tachycardia, tremor
iii. moist skin, headache, hunger
iv. nausea, bloating, diarrhea
e. contraindications:
i. hypersensitivity
f. nursing interventions
i. assess client for effect of medication
ii. monitor blood/urine glucose levels
iii. guidelines for administration of insulin
• rotate sites
• administered subcutaneously
• only regular insulin is administered IV
• when mixing insulin, regular insulin is withdrawn into the syringe first
iv. instruct client
• how to administer the medication
• compliance with dietary restrictions
• urine and blood testing
• wear medic alert jewelry
• how to cope with hypoglycemic reactions
• signs of ketoacidosis
• importance of weight loss if obese
Pancreatic enzymes
a. action: replacement for natural pancreatic enzymes
b. examples
i. pancreatin (Dizymes)
ii. pancrelipase (Cotazym)
c. use: aid in digestion; cystic fibrosis
d. adverse reactions, with large doses
i. diarrhea
ii. nausea
iii. hypersensitivity reaction: sneezing, skin rashes
e. contraindications
i. hypersensitivity to pork
ii. chronic pancreatic disease
f. nursing interventions
i. monitor for symptoms of diabetes mellitus (such as polyuria, thirst, hunger)
ii. monitor weight, intake and output
iii. administer with meals
iv. do not crush enteric coated medications
v. determine client's response to therapy
Laxatives
a. action: moves stool; mechanism dependent on type of laxative
b. examples
i. lubricants moisten stool; mineral oil
ii. stool softeners allow water to penetrate stool; dioctyl sodium sulfosuccinate (Colace)
iii. bulk forming: increase bulk in intestine; psyllium hydrophilic mucilloid (Metamucil)
iv. colon irritant stimulates peristalsis; bisacodyl (Dulcolax)
v. saline cathartics increase osmotic pressure thereby absorbing fluid from bowel wall; milk of magnesia
c. use: to treat constipation
d. adverse reactions
i. gastric effects: nausea, cramping, diarrhea
ii. dependence with long-term use
iii. intestinal lubricants inhibit absorption of fat-soluble vitamins
iv. saline cathartics: dehydration, hypernatremia
e. contraindications:
i. GI obstruction
ii. suspected appendicitis
iii. megacolon
iv. abdominal pain
v. nausea
f. nursing interventions
i. monitor effects of medication
ii. teach client
• dietary considerations (increased fiber and fluid intake)
• maintain/increase activity level
• caution regarding overuse of laxatives
• mix bulk-forming laxatives with a glass of water and follow with another glass of water
b. examples
i. lubricants moisten stool; mineral oil
ii. stool softeners allow water to penetrate stool; dioctyl sodium sulfosuccinate (Colace)
iii. bulk forming: increase bulk in intestine; psyllium hydrophilic mucilloid (Metamucil)
iv. colon irritant stimulates peristalsis; bisacodyl (Dulcolax)
v. saline cathartics increase osmotic pressure thereby absorbing fluid from bowel wall; milk of magnesia
c. use: to treat constipation
d. adverse reactions
i. gastric effects: nausea, cramping, diarrhea
ii. dependence with long-term use
iii. intestinal lubricants inhibit absorption of fat-soluble vitamins
iv. saline cathartics: dehydration, hypernatremia
e. contraindications:
i. GI obstruction
ii. suspected appendicitis
iii. megacolon
iv. abdominal pain
v. nausea
f. nursing interventions
i. monitor effects of medication
ii. teach client
• dietary considerations (increased fiber and fluid intake)
• maintain/increase activity level
• caution regarding overuse of laxatives
• mix bulk-forming laxatives with a glass of water and follow with another glass of water
Anti-diarrheal
a. action: forms the stool; mechanism depends on type of medication
b. examples
i. fluid absorbents - decrease fluid content; kaolin and pectin (Kaopectate)
ii. motility suppressants - decrease motility of GI tract; diphenoxylate HCL (Lomotil), loperamide HCL (Imodium)
iii. enteric bacterium - replacements help intestine turn carbohydrates into lactic acid; lactobacillus acidophilus (Bacid)
c. use: treat diarrhea
d. adverse reactions
i. fluid absorbents: gastric disturbances, CNS toxicity
ii. enteric bacterium replacements: excessive flatulence, abdominal cramps
iii. motility suppressants: urinary retention, tachycardia, sedation, paralytic ileus, respiratory depression
e. contraindications:
i. ulcerative colitis
f. nursing interventions
i. monitor effect of medication
ii. assess for fluid and electrolyte imbalance
iii. assess for cause of diarrhea
iv. motility suppressants may cause physical dependence, may impair ability to perform hazardous activities
b. examples
i. fluid absorbents - decrease fluid content; kaolin and pectin (Kaopectate)
ii. motility suppressants - decrease motility of GI tract; diphenoxylate HCL (Lomotil), loperamide HCL (Imodium)
iii. enteric bacterium - replacements help intestine turn carbohydrates into lactic acid; lactobacillus acidophilus (Bacid)
c. use: treat diarrhea
d. adverse reactions
i. fluid absorbents: gastric disturbances, CNS toxicity
ii. enteric bacterium replacements: excessive flatulence, abdominal cramps
iii. motility suppressants: urinary retention, tachycardia, sedation, paralytic ileus, respiratory depression
e. contraindications:
i. ulcerative colitis
f. nursing interventions
i. monitor effect of medication
ii. assess for fluid and electrolyte imbalance
iii. assess for cause of diarrhea
iv. motility suppressants may cause physical dependence, may impair ability to perform hazardous activities
Antiulcers
a. actions
i. decrease acetylcholine release
ii. block release of histamines
iii. inhibit secretion of pepsin
iv. inhibit proton pump
b. examples
i. anticholinergics; belladonna tincture, chlorodiazepoxide (Librax)
ii. h2 blockers - cimetidine (Tagamat), ranitidine (Zantac)
iii. pepsin inhibitor - sucralfate (Carafate)
iv. proton pump inhibitor - lansoprazole (Prevacid), omeprazole (Prilosec)
c. uses: management of peptic ulcer disease, gastroesophageal reflux disease(GERD), protects gastric mucosa from hydrochloric acid production
d. adverse reactions
i. dry mouth, decreased secretions, constipation, tachycardia, & urinary retention
ii. headaches, dizziness, constipation, skin reash, pruritis, impotence
iii. sucralfate is nonabsorbable, occasional constipation
e. contraindications
i. anticholinergics - narrow- angle glaucoma
ii. renal failure
iii. liver disease
f. nursing interventions
i. administer on empty stomach
ii. avoid antacids within 30 minutes of sucralfate
iii. avoid antacids within one to two hours of other antiulcer drugs
iv. administer other drugs one to two hours after sucralfate
v. teach clients
• avoid alcohol, spicy food, and caffeinated beverages
• eliminate smoking
• increase fluid intake
• medication can take up to two weeks for full effect
• report increasing abdominal pain, vomiting of blood, or passage of bloody stools
Antacids
a. action
i. neutralizes gastric acid
ii. coats stomach lining
b. examples
i. aluminum hydroxide gel (Amphojel)
ii. aluminum and magnesium hydroxides (Maalox)
iii. magaldrate (Riopan)
c. use: peptic ulcers, reflux esophagitis, hiatal hernia
d. adverse reactions
i. aluminum compounds - constipation, intestinal obstruction
ii. magnesium compounds - diarrhea
iii. reduced absorption of calcium and iron
e. nursing interventions
i. shake oral suspension well
ii. monitor client's response to treatment
iii. administer with 8 oz glass of water
iv. teach client
• avoid overuse of antacids
• dietary restrictions for ulcers
• need for diet high in calcium and iron
• for clients on low sodium diets: antacids contain sodium
• may color stools whitish
Antiemetics
a. action - prevent expulsion of stomach contents by decreasing stimulation of either the chemoreceptor trigger zone (CTZ), near the medulla, or the vomiting center in the medulla
b. examples
i. antihistamines: dimenhydrinate (Dramamine), promethazine (Phenergan)
ii. anticholinergic: scopolamine (Transderm- Scop)
iii. phenothiazines;chlorprimazine (Thorazine), prochlorperazine (Compazine)
iv. seratonin (5-HT3) receptor antagonist; granisetron (Kytril), odansetron (Zofran)
c. use: prevent nausea and vomiting; cause must be identified to prevent masking a serious problem
d. adverse reactions
i. tachycardia, hypotension
ii. dry mouth and eyes, blurred vision, constipation
iii. sedation, drowsiness
e. contraindications
i. narrow-angle glaucoma
ii. liver disease
iii. intestinal obstrucion
iv. depression
f. nursing interventions
i. use nonpharmacologic measures first (tea, crackers, dry toast)
ii. monitor vital signs
iii. monitor for signs and symptoms of shock if vomiting severe
iv. monitor bowel sounds
v. provide mouth care after vomiting
vi. teach client
• store drug in tight, light resistant container
• avoid OTC drugs
• avoid alcohol because of cumulative sedative effects
• avoid during first trimester of pregnancy
b. examples
i. antihistamines: dimenhydrinate (Dramamine), promethazine (Phenergan)
ii. anticholinergic: scopolamine (Transderm- Scop)
iii. phenothiazines;chlorprimazine (Thorazine), prochlorperazine (Compazine)
iv. seratonin (5-HT3) receptor antagonist; granisetron (Kytril), odansetron (Zofran)
c. use: prevent nausea and vomiting; cause must be identified to prevent masking a serious problem
d. adverse reactions
i. tachycardia, hypotension
ii. dry mouth and eyes, blurred vision, constipation
iii. sedation, drowsiness
e. contraindications
i. narrow-angle glaucoma
ii. liver disease
iii. intestinal obstrucion
iv. depression
f. nursing interventions
i. use nonpharmacologic measures first (tea, crackers, dry toast)
ii. monitor vital signs
iii. monitor for signs and symptoms of shock if vomiting severe
iv. monitor bowel sounds
v. provide mouth care after vomiting
vi. teach client
• store drug in tight, light resistant container
• avoid OTC drugs
• avoid alcohol because of cumulative sedative effects
• avoid during first trimester of pregnancy
Antiinflammatory (steroids, glucocorticoids)
a. action: stabilize leukocyte lysosomal membranes, inhibit phagocytosis and release of allergic substances
b. examples
i. hydrocortisone sodium succinate (Solu-Cortef)
ii. hydrocortisone sodium phosphate (Hydrocortone)
c. use: to suppress inflammatory or immune responses
d. adverse reactions
i. sodium and fluid retention
ii. nausea, acne, impaired wound healing
iii. anaphylactic reaction
iv. masking of infection
v. behavior changes
e. contraindications
i. hypersensitivity
ii. systemic fungal infections
f. nursing interventions
i. establish baseline of vital signs, I/O ratio, weight
ii. monitor blood pressure during stabilization period
iii. assess client's response to treatment
iv. teach client
• take oral steroid with food
• take anti-inflammatories on schedule and don't stop abruptly
• expect a slight weight gain
• avoid alcohol and caffeine
• do not use OTC medications unless approved by health care provider
• report slow healing, vague feeling of being sick, or relapse
• use medic alert jewelry or ID
b. examples
i. hydrocortisone sodium succinate (Solu-Cortef)
ii. hydrocortisone sodium phosphate (Hydrocortone)
c. use: to suppress inflammatory or immune responses
d. adverse reactions
i. sodium and fluid retention
ii. nausea, acne, impaired wound healing
iii. anaphylactic reaction
iv. masking of infection
v. behavior changes
e. contraindications
i. hypersensitivity
ii. systemic fungal infections
f. nursing interventions
i. establish baseline of vital signs, I/O ratio, weight
ii. monitor blood pressure during stabilization period
iii. assess client's response to treatment
iv. teach client
• take oral steroid with food
• take anti-inflammatories on schedule and don't stop abruptly
• expect a slight weight gain
• avoid alcohol and caffeine
• do not use OTC medications unless approved by health care provider
• report slow healing, vague feeling of being sick, or relapse
• use medic alert jewelry or ID
Anti-infectives
a. action: interfere with essential metabolic actions of microbial cells
b. examples
i. silver sulfadiazine (Silvadene)
ii. silver nitrate 0.1%-0.5% solution
c. uses
i. ophthalmic solutions: treat ophthalmic infections
ii. bladder and urethra irrigations
d. adverse effects
i. silver sulfadiazine: skin irritation
ii. silver nitrate
• electrolyte imbalance
• brownish black discoloration produced on contact
e. nursing interventions
i. monitor client's condition during treatment
ii. for eyes, use only silver nitrate in ophthalmic solution
iii. handle silver nitrate with care: solutions stain skin and clothing
iv. silver sulfadiazine: use aseptic technique when applying
b. examples
i. silver sulfadiazine (Silvadene)
ii. silver nitrate 0.1%-0.5% solution
c. uses
i. ophthalmic solutions: treat ophthalmic infections
ii. bladder and urethra irrigations
d. adverse effects
i. silver sulfadiazine: skin irritation
ii. silver nitrate
• electrolyte imbalance
• brownish black discoloration produced on contact
e. nursing interventions
i. monitor client's condition during treatment
ii. for eyes, use only silver nitrate in ophthalmic solution
iii. handle silver nitrate with care: solutions stain skin and clothing
iv. silver sulfadiazine: use aseptic technique when applying
Antipruritics
a. action: inhibits conduction of nerve impulses to sensory endings
b. examples -
i. benzocaine (Solarcaine)
ii. lidocaine HCL (Xylocaine)
c. use: temporary relief of skin problems such as minor burns, insect bites, sunburn
d. adverse reactions - skin irritation
e. nursing interventions
i. monitor effect of treatment
ii. avoid contact with eyes
b. examples -
i. benzocaine (Solarcaine)
ii. lidocaine HCL (Xylocaine)
c. use: temporary relief of skin problems such as minor burns, insect bites, sunburn
d. adverse reactions - skin irritation
e. nursing interventions
i. monitor effect of treatment
ii. avoid contact with eyes
Scabicides/pediculicides
a. action: targets the parasite's nerve-cell membrane
b. examples
i. permethrin (Nix, Elimite)
ii. lindane (Kwell)
c. use: treat parasitic arthropods: itch mites (scabies) and lice
d. adverse reaction: skin irritation
e. contraindications: hypersensitivity
f. nursing interventions
i. use precautions to prevent spread of parasites (for example, use gown and gloves, keep infected linen separate, etc.)
ii. keep medication away from eyes and mucous membranes
iii. monitor for skin irritation
iv. determine source of contamination
v. evaluate effectiveness of treatment
b. examples
i. permethrin (Nix, Elimite)
ii. lindane (Kwell)
c. use: treat parasitic arthropods: itch mites (scabies) and lice
d. adverse reaction: skin irritation
e. contraindications: hypersensitivity
f. nursing interventions
i. use precautions to prevent spread of parasites (for example, use gown and gloves, keep infected linen separate, etc.)
ii. keep medication away from eyes and mucous membranes
iii. monitor for skin irritation
iv. determine source of contamination
v. evaluate effectiveness of treatment
Iron supplements
a. action: iron transported as transferrin to bone marrow and incorporated into hemoglobin
b. examples
i. ferrous sulfate (Feosol)
ii. ferrous fumarte (Feco-T)
iii. ferrous gluconate (Fergon)
c. use: correct simple iron deficiency anemia
d. adverse effects
i. gastric disturbances
ii. with massive overdose - lethargy, drowsiness, leading to metabolic acidosis, shock and cardiovascular collapse
e. contraindications:
i. hypersensitivity
ii. ulcerative colitis
iii. peptic ulcer disease
iv. hemolytic anemia
v. cirrhosis
f. nursing interventions
i. monitor hemoglobin level
ii. teach client
• take on empty stomach
• liquid preparation - take with a straw to prevent tooth discoloration
• protect from moisture and heat
• may cause dark or greenish stools
b. examples
i. ferrous sulfate (Feosol)
ii. ferrous fumarte (Feco-T)
iii. ferrous gluconate (Fergon)
c. use: correct simple iron deficiency anemia
d. adverse effects
i. gastric disturbances
ii. with massive overdose - lethargy, drowsiness, leading to metabolic acidosis, shock and cardiovascular collapse
e. contraindications:
i. hypersensitivity
ii. ulcerative colitis
iii. peptic ulcer disease
iv. hemolytic anemia
v. cirrhosis
f. nursing interventions
i. monitor hemoglobin level
ii. teach client
• take on empty stomach
• liquid preparation - take with a straw to prevent tooth discoloration
• protect from moisture and heat
• may cause dark or greenish stools
Hematopoietic growth agent
a. action: stimulates production, growth, maturation, and differentiation of bone marrow stem cells
b. example
d. adverse effects
i. filgrastim: bone pain
ii. epoetin alfa: hypertension, headache, joint pain
e. contraindications
i. hypersensitivity to proteins of E. Coli
f. nursing interventions
i. take baseline CBC and diff (complete blood count and differential count) prior to treatment
ii. monitor lab results until target reached
b. example
- i. filgrastim (Neupogen)- stimulates production of white blood cells
- ii. epoetin alfa (Epogen)- stimulates production of red blood cells
d. adverse effects
i. filgrastim: bone pain
ii. epoetin alfa: hypertension, headache, joint pain
e. contraindications
i. hypersensitivity to proteins of E. Coli
f. nursing interventions
i. take baseline CBC and diff (complete blood count and differential count) prior to treatment
ii. monitor lab results until target reached
Hematopoietic growth agent
a. action: stimulates production, growth, maturation, and differentiation of bone marrow stem cells
b. example
d. adverse effects
i. filgrastim: bone pain
ii. epoetin alfa: hypertension, headache, joint pain
e. contraindications
i. hypersensitivity to proteins of E. Coli
f. nursing interventions
i. take baseline CBC and diff (complete blood count and differential count) prior to treatment
ii. monitor lab results until target reached
b. example
- i. filgrastim (Neupogen)- stimulates production of white blood cells
- ii. epoetin alfa (Epogen)- stimulates production of red blood cells
d. adverse effects
i. filgrastim: bone pain
ii. epoetin alfa: hypertension, headache, joint pain
e. contraindications
i. hypersensitivity to proteins of E. Coli
f. nursing interventions
i. take baseline CBC and diff (complete blood count and differential count) prior to treatment
ii. monitor lab results until target reached
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